Ocular surface sphingolipids associate with the refractory nature of vernal keratoconjunctivitis: newer insights in VKC pathogenesis.

Vignesh Menta,Shweta Agarwal,Ujjalkumar Subhash Das,Laxmi Moksha,Gurumurthy Srividya, Amrutha M Anandan,Bhaskar Srinivasan,Geetha Iyer,Thirumurthy Velpandian,Narayanasamy Angayarkanni

The British journal of ophthalmology（2023）

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摘要

Altered sphingolipid metabolism in the ocular surface results in low tear ceramide and sphingosine levels in severe/very severe VKC compared with the mild/moderate cases. The novel finding opens up fresh targets for intervention in these refractory cases.

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关键词

biochemistry,conjunctiva,immunology,inflammation,ocular surface

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