(R) Corresponding author: Wenjie Li, DDS, MSD, MSc, . Telephone:+86-181-8212-9707 (Office), Fax: 0731-84805086. E-mail: liwenj@csu.edu.cn.

The Hippo pathway plays an important role in many pathophysiological processes, including cell proliferation and differentiation, cell death, cell migration and invasion. Because of its extensive functions, Hippo pathway is closely related to not only growth and development, but also many diseases, including inflammation and cancer. In this study, the role of Hippo pathway in craniofacial diseases and hard tissue remodeling was reviewed, in attempting to find new research directions.