Three-dimensional organoid culture unveils resistance to clinical therapies in adult and pediatric glioblastoma

Swetha J. Sundar,Sajina Shakya, Austin Barnett,Lisa C. Wallace,Hyemin Jeon,Andrew Sloan,Violette Recinos,Christopher G. Hubert

Translational Oncology（2022）

引用 27|浏览8

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摘要

•Glioblastoma organoid cultures preserve diversity of proliferative cell phenotypes.•Heterogeneous 3D cultures recapitulate resistance to clinical GBM therapeutics.•Patient specimens show different behavior depending on 2D vs 3D growth.

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关键词

Glioblastoma,Organoids,Tumor microenvironments,Therapeutic resistance,Chemotherapy

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