Focused Ultrasound-Mediated Blood-Brain Barrier Opening Enhances Panobinostat Efficacy in a Murine Diffuse Intrinsic Pontine Glioma Model.

H. J. Wei,A. Pouliopoulos,N. Yoh, M. Tazhibi,N. McQuillan,X. Zhang,L. Szalontay,R. Gartrell, P. Jovana,Z. Zhang,N. Feldstein,S. Zacharoulis,E. E. Konofagou,C. C. Wu

International journal of radiation oncology, biology, physics（2021）

引用 2|浏览16

暂无评分

摘要

The current results demonstrate that FUS could increase the treatment efficacy of panobinostat in a DIPG animal model due to the improved targeted dose of systemic panobinostat in the DIPG tumors. We believe these data establish a strong preclinical rationale to assess the combination of FUS-mediated BBB opening with panobinostat in pediatric patients with DIPG.

查看译文

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要