Clinical Behavior and Outcome of HPV-Positive Nasopharyngeal Carcinoma.

HPV+ NPC is an emerging entity, of which about one-third are caused by non-HPV-16 genotype. Compared with the more common EBV+ NPC cases, HPV+ NPC presents with more local pain and advanced T categories but has similar outcomes. HPV+ NPC also has similar outcomes to HPV+ OPC except that DC is lower in univariable analysis, possibly attributable to higher T category and non-HPV-16 genotypes. There may be a role for modification of systemic therapy in HPV+ NPC to address distant failure risk.