Scaffolding Proteins in Pediatric Glioma

and migration are important during lifetime, from very early embryonic development on up to aging individuals. Proteins regulating these events may play different roles regarding the biological age of a human. However, certain functional aspects of molecular regulators may be conserved throughout lifetime. This is due to physical interactions between proteins and concertation of key organizers such as scaffolding proteins which bring certain important signaling molecules in contact which each other to control these processes [1]. As this is true in normal functioning cells, in pathological conditions such as cancer, interactions between scaffolding proteins and target molecules are altered and physiological processes are deregulated [2] (see Figure 1A).