Age-related alterations to working memory and to pyramidal neurons in the prefrontal cortex of rhesus monkeys begin in early middle-age and are partially ameliorated by dietary curcumin.

W Chang, C M Weaver,M Medalla,T L Moore,J I Luebke

Neurobiology of Aging（2022）

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摘要

•Spatial working memory (WM) performance begins to decline in middle age•Pyramidal neurons exhibit hyperexcitability and spine loss beginning in middle age•Curcumin-treated subjects exhibit better WM ability and less neuronal excitability

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关键词

Working memory,In vitro slice,Electrophysiology,Morphology,Delayed Recognition Span Task

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