Identification of Novel Biomarkers and Pathways for Coronary Artery Calcification in Nondiabetic Patients on Hemodialysis Using Metabolomic Profiling.

Wei Chen,Jessica Fitzpatrick,Stephen M Sozio,Bernard G Jaar,Michelle M Estrella,Dario F Riascos-Bernal,Tong Tong Wu,Yunping Qiu,Irwin J Kurland,Ruth F Dubin,Yabing Chen,Rulan S Parekh,David A Bushinsky,Nicholas E S Sibinga

Kidney360（2021）

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摘要

Among patients on HD without diabetes mellitus, chenodeoxycholic, deoxycholic, and glycolithocholic acids may be potential biomarkers for CAC, and arginine/proline metabolism is a plausible mechanism to study for CAC. These findings need to be confirmed in future studies.

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关键词

mineral metabolism,arginine and proline metabolism,arterial calcification,bile acid,coronary artery disease,dialysis,metabolomics

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