A functional and self-assembling octyl-phosphonium-tagged esculetin as an effective siRNA delivery agent
CHEMICAL COMMUNICATIONS(2021)
摘要
Herein, we document a self-assembling octyl-TPP tagged esculetin (Mito-Esc) as functionally active and as a novel small molecule siRNA delivery vector. While Mito-Esc itself induces selective breast cancer cell death, the amphiphilic nature of Mito-Esc delivers therapeutic siRNAs intracellularly without the need for any excipient to exacerbate the anti-proliferative effects.
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关键词
siRNA Delivery
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