DNA methylation profile in patients with indolent systemic mastocytosis.

Aleksandra Górska,Ewa Jabłońska,Edyta Reszka,Marek Niedoszytko,Magdalena Lange,Marta Gruchała-Niedoszytko,Justyna Jarczak,Dominik Strapagiel,Magdalena Górska-Ponikowska,Paulina Bastian,Iwona Pelikant-Małecka,Leszek Kalinowski,Bogusław Nedoszytko

ALLERGY（2021）

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摘要

Decreased DNA demethylation in the blood DNA of patients with ISM confirms that epigenetic alterations are involved in mastocytosis pathology. We observed a possible role of allergy as an important epigenetic modifier. There is a possible association between KIT mutations and the methylation status observed in human mast cell lines.

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关键词

DNA methylation,KIT mutation,epigenetics,mastocytosis

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