A four-probiotic preparation for ventilator-associated pneumonia in multi-trauma patients: results of a randomized clinical trial

Maria Tsilika,Giannoula Thoma,Zoi Aidoni,Georgia Tsaousi,Kyriakos Fotiadis,George Stavrou,Petra Malliou,Angeliki Chorti, Helen Massa,Elli Antypa, Georgia Vasiliadou, Kyriaki Pagdatoglou, Antonios Voudouris, Spyridoula Vasiliagou,Giakoumis Mitos, Ntina Kontopoulou, Niki Paraforou,Eleni Antoniadou, Helen Mouloudi,Eleni Gkeka

International Journal of Antimicrobial Agents（2022）

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摘要

•Prophylactic intake of probiotics by multi-trauma patients reduced the incidence of ventilator-associated mpneumonia.•The probiotic preparations contained four different probiotic species.•The time to cessation of vasopressors and length of ICU stay were reduced.•No safety concerns were raised.

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Probiotics,Mechanical ventilation,Pneumonia,Sepsis,Safety,Oropharynx

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