Mutational profiles of primary pulmonary adenocarcinoma and paired brain metastases disclose the importance of KRAS mutations

•Molecular analysis of paired lung cancers and brain metastases puts focus on KRAS.•KRAS alterations are more frequent in lung cancer with brain metastases.•Additional KRAS alterations are a frequent event private to brain metastases.•Among KRAS mutations, G12C and G13C variants are significantly more frequent.