Genetic variations within human gained enhancer elements affect human brain sulcal morphology

Herve Lemaitre,Yann Le Guen,Amanda K Tilot,Jason L Stein,Cathy Philippe,Jean-François Mangin,Simon E Fisher,Vincent Frouin

NeuroImage（2023）

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摘要

•Integration of evolutionary signatures with neuroimaging and genetic data from the UK biobank.•Contributions of genomic annotations spanning 30 million years to human sulcal morphology.•Genetic variations within human gained enhancers explained more trait heritability than expected for the left and right calloso-marginal posterior fissures and the right central sulcus.

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关键词

Sulcal morphology,Human gained enhancers,Neuroimaging,Genome-wide association,Evolution

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