Potential added value of combined DPYD/DPD genotyping and phenotyping to prevent severe toxicity in patients with a DPYD variant and decreased dihydropyrimidine dehydrogenase enzyme activity.
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners(2023)
摘要
Our results indicate that a combined genotype-phenotype approach could be useful to identify patients at increased risk for fluoropyrimidine-associated toxicity (e.g. patients with a variant and decreased dihydropyrimidine dehydrogenase activity). Because the group sizes are too small to demonstrate statistically significant differences, this warrants further research in a prospective study in a larger cohort.
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关键词
DPD,DPD deficiency,DPYD,decreased DPD activity,fluoropyrimidine toxicity,fluoropyrimidines,pharmacogenetics
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