Effects Of Resveratrol On Spermatogenic Function In Rats With Type 2 Diabetes

Objective: The aim of this study was to investigate the effects of resveratrol on Bcl-2, Bax, and SOD expression and spermatogenic function in testicular tissues of rats with type 2 diabetes. Methods: A total of 40 pathogen-free, mature, male SD rats were selected. Ten rats were randomly selected as the control group using a random number table. The remaining 30 rats were induced to develop type 2 diabetes. The model was successfully established. The rats were then randomly divided into the model group and treatment group. Expression of Bcl-2, Bax, and SOD protein and spermatogenic function were determined in testicular tissues. Effects and mechanisms of resveratrol on spermatogenic function in rats with type 2 diabetes were analyzed. Results: After 13 weeks of treatment, expression of Bcl-2, Bax, and SOD was significantly different in the three groups (P<0.001). Testicular index (P=0.001, P=0.042), testicular volume (P=0.001, P=0.045), sperm concentrations (all P<0.001), capacity of action (P<0.001, P=0.005), survival rates (P<0.001, P=0.010), and malformation rates (all P<0.001) in the model and treatment groups were lower than those in the control group. Values were higher in the treatment group than in the model group (P=0.046, P<0.001, P<0.001, P<0.001, P<0.001, P<0.001). Conclusion: Resveratrol improved the reproductive function of rats with type 2 diabetes. Underlying mechanisms were likely that it protects against oxidative stress damage and spermatogenic cell apoptosis in testicular tissues.