Expression Of Glycine Decarboxylase In Epithelial Ovarian Cancers And Its Association With Prognosis

GLDC is aberrantly overexpressed in numerous malignant tumors, associated with poor survival of patients, but in epithelial ovarian cancers, the expression and function of GLDC is unclear. In this study, we mainly discuss expression, distribution, and prognostic significance of GLDC in epithelial ovarian cancers. The expression of GLDC were detected by immunohistochemistry (IHC), then the staining was evaluated, the clinical and pathologic characteristics, overall survival (OS), progress free survival (PFS) were analyzed. The results indicated that GLDC expression is up-regulated in the epithelial ovarian cancers compared to benign tumor tissues. The expression of GLDC is significantly correlated with FIGO stage (P=0.018), lymph node metastasis (P=0.023), residual tumor size (P=0.020), while it isn't correlated with other clinical features. In a Kaplan Meier analysis, the higher expression of GLDC was correlated with poor OS and PFS. Therefore, GLDC may be a significant prognostic factor in epithelial ovarian cancers and useful to further clinical trials.