The Safety And Efficacy Of Interstitial I-125 Seed Implantation Brachytherapy For Metastatic Epidural Spinal Cord Compression

Objective: The objective of this study is to investigate the safety and efficacy of I-125 seed interstitial implantation brachytherapy for metastatic epidural spinal cord compression (MESCC) as well as the life quality of patients.Materials and Methods: From April 2009 to May 2015, 28 patients who met the eligibility criteria were retrospectively reviewed. The number of implanted I-125 seeds ranged from 7 to 62, with appropriate activity of 0.5-0.8 mCi. The postplan showed that the matched peripheral dose (MPD) of tumors was 80-140 Gy. The duration of follow-up ranged from 1 to 32 months with a median of 18 months. Visual analog scale (VAS), Karnofsky Performance Scale (KPS), and motor performance were evaluated before and after treatment.Results: Seed implantation was well tolerated by all patients. Pain was obviously alleviated in all patients. VAS score of patients was significantly decreased from 4.89 +/- 1.52 before treatment to 1.61 1.20 after treatment, and KPS score was significantly increased from 73.93 +/- 12.27 to 86.76 +/- 10.90 (P < 0.05). The local control rates of 1, 2, and 3 years were 77%, 34%, and 14%, respectively, with a median of 19 months (7-32 months). The survival rates of 1, 2, and 3 years were 81%, 54%, and 14%, respectively, with a median of 25 months. Seven (100%) nonwalking patients regained motor ability. No myelopathy or other neurologic sequelae were encountered.Conclusion: Interstitial I-125 seed implantation brachytherapy may be a promising local therapy, which was an alternative and palliative way for treating MESCC.