The Expressions And A Correlation Analysis Of Mir-155 And Mir-27b In Mycobacterium Brain Abscess

miR-27b is associated with inflammation, and miR-155 is involved in the regulation of mycobacterium tuberculosis. However, the expressions and correlation of miR-155 and miR-27b in mycobacterial brain abscess remain unclear. New Zealand white rabbits were randomly divided into a control group and a brain abscess group. 1x10(7) CFU/mL Mycobacterium tuberculosis suspension was injected intracranially through the skull followed by an analysis of the cerebrospinal fluid and the expressions of miR-155 and miR-27b by real time PCR. The correlations between miR-155 and miR-27b and cerebrospinal fluid pressure, cerebrospinal fluid cell number, protein, sugar, and chloride content were analyzed. In the brain abscess group, the cerebrospinal fluid pressure, the cerebrospinal fluid cell number, and the protein content significantly increased, and the sugar and chloride content decreased with an increased miR-155 level and decreased miR-27b level compared with the control group (P < 0.05). miR-155 was positively correlated with cerebrospinal fluid pressure, the cerebrospinal fluid cell number, the protein content and negatively correlated with the sugar and chloride content (P < 0.05). On the other hand, miR-27b had a negative correlation with the cerebrospinal fluid pressure, the cerebrospinal fluid cell number, and the protein content, and a positive correlation with sugar and chloride content (P < 0.05). In addition, miR-155 and miR-27b were negatively correlated. The miR-155 expression was increased and miR-27b was decreased in mycobacterial brain abscess. miR-155 and miR-27b were negatively correlated. The combined detection of miR-155 and miR-27b was beneficial to the diagnosis of mycobacterial brain abscess.