Synthesis And Anticonvulsant Activity Of 5-Substituted 1h-Tetrazoles Against Pentylenetetrazole-Induced Seizures

Nine 5-Substituted 1H-tetrazole derivatives (T1-T9) in two categories (phenyl tetrazole and phenylmethyl tetrazole) were synthesized by cycloaddition of a nitrile compounds with sodium azide using nano-SnCl4-SiO2 as a mild catalyst in good yield.The subcutaneous pentylenetetrazole (PTZ) seizure models were used for screening the anticonvulsant activity of the compounds. Male BALB/c mice received increasing doses of tetrazole derivatives (10, 20 and 30 mg/kg). After 30 minutes, the myoclonic and generalized seizures latencies induced by pentylenetetrazole (85 mg/kg) was measured and compared to diazepam as a positive control. Our results showed, compounds T1, T3, and T7 revealed significant anticonvulsant activity in the PTZ test.