Prophylactic efficacy of two anticoagulant drug heparin calcium and rivaroxaban, on venous thrombosis after knee arthroplasty

Objective: It is aimed to analyze the effect of low molecular weight heparin calcium and rivaroxaban on the prevention of venous thrombosis after knee arthroplasty. Methods: 81 gonarthrosis patients who were treated with knee arthroplasty in our hospital were selected as objects of study for retrospective analysis and divided into 2 groups accord ingto the order of admission, including 40 patients treated with low molecular weight heparin calcium after operation in control group and 41 patients treated with rivaroxaban after operation in observation group, so as to compare the incidence of venous thrombosis, total blood loss, overt blood loss, platelet count, hemoglobin level, coagulation function and incidence of bleeding events after operation in two groups. Results: (1)After operation, the incidence of lower limb venous thrombosis was 7.32% in observation group and 25.00% in control group (P<0.05). (2) The total blood loss was 1125.63 +/- 245.89 ml in observation group and 1088.25 +/- 231.48 ml in control group after operation. The overt blood loss was 435.29 +/- 67.81 ml in observation group and 395.23 +/- 51.26 ml in control group after operation (P>0.05). (3) There was no statistical difference in Hb, PLT, PT, APTT and D-D before operation and 10 days after operation in two groups (P>0.05). (4) There was no statistical difference in the incidence of bleeding events 1 month after operation in two groups (P>0.05). (5) There was no statistical difference in the decreased levels of wound drainage, blood transfusion and hemoglobin in two groups (P>0.05). Conclusions: The application of low molecular weight heparin calcium and rivaroxaban to knee arthroplasty could control the bleeding and reduce the incidence of bleeding events, without any obvious influence on coagulation function. But the application of rivaroxaban could reduce the incidence of postoperative venous thrombosis more obviously, so it was more worthy of popularization and application.