Effects Of Spinal Anesthesia Combined With Dexmedetomidine On Patients With Infected Urinary Calculus

Objective: To investigate the effects of spinal anesthesia (SA) combined with dexmedetomidine (Dex) on patients with infected urinary calculus. Methods: A total of 105 patients with infected urinary calculus admitted to Affiliated Cixi Hospital, Wenzhou Medical University were enrolled, of which 55 patients were given both SA and Dex as a SD group, and the rest were given SA alone as a SA group. The procalcitonin (PCT), interleukin-1 (IL-1), and cystatin C (CysC) in the serum of the patients were determined, and the effect of SD combined with SA on those factors in the patients was analyzed. The following items of the two groups were compared: operation time, intraoperative blood loss, visual analogue scale (VAS) score, hospitalization time, and incidence of postoperative complications. In addition, the risk factors affecting the postoperative complications of the patients were analyzed. Results: The incidence of postoperative complications, operation time, intraoperative blood loss, VAS score, hospitalization time, mean arterial pressure (MAP), and heart rate (HR) of the SD group were significantly lower than those of the SA group, and the two groups were not significantly different in the arterial blood oxygen saturation (SPO2). Moreover, after operation, the PCT, IL-1, and CysC levels of the SD group were significantly lower than those of the SA group, and multiple calculi, diabetes mellitus, PCT, IL-1, CysC, and SA alone were risk factors for postoperative complications in the patients with infected urinary calculus. Conclusion: SA combined with Dex is beneficial to suppress inflammatory response in patients and improve their hemodynamic parameters, and it is also helpful to shorten their operation time and hospitalization time, reduce their intraoperative blood loss and postoperative complications, and alleviate their pain.