F-18-Labeling Of Sensitive Biomolecules For Positron Emission Tomography

Positron emission tomography (PET) imaging study of fluorine-18 labeled biomolecules is an emerging and rapidly growing area for preclinical and clinical research. The present review focuses on recent advances in radiochemical methods for incorporating fluorine-18 into biomolecules via direct or indirect bioconjugation. Recently developed prosthetic groups and pre-targeting strategies, as well as representative examples in F-18-labeling of biomolecules in PET imaging research studies are highlighted.