Resveratrol Attenuates Obesity Related Renal and Systemic Alterations During Acute and Chronic Endoplasmic Reticulum Stress

Renal lipid accumulation has been associated with chronic renal failure in obese patients. Molecular mechanisms seem to implicate lipotoxicity and induction of endoplasmic reticulum (ER) stress. Resveratrol (R) is a natural bioactive compound that elicits benefits over some obesity–related metabolic disorders. The objective of this study was to evaluate the effect of R supplementation on a high fat (HF) diet over a chronic and acute induction of ER stress in C57BL/6 mice. Male mice were fed for 28 weeks with four different dietary treatments: Control (C), C+R (CR), HF, and HF+R (HFR). At the end of the study, half of the animals on each group were treated with tunicamycin (T) to induce acute ER stress. Weight gain, glucose tolerance test (GTT), indirect calorimetry and serum biomarkers were analyzed. Weight gain of the HFR group was lower than HF accompanied with a significant increase in O2 consumption and CO2 production during fasting and fed state. Mice in the HF and HFR groups had lower glucose tolerance compared to C and CR. Total‐ and LDL‐cholesterol were lower in HFR group compared to HF group. Mice treated with T had lower glucose, total‐ and LDL‐cholesterol compared to C and HF groups. No differences were observed in other biomarkers (albumin, creatinine, AST, ALT and triglycerides) in CR+T and HFR+T groups despite the acute ER stress induction. In conclusion, resveratrol supplementation showed beneficial effects on body weight gain, energy expenditure and biochemical variables with and without pharmacological induction of ER stress.