Chiroptical Spectroscopy As A Sensitive Tool For The Conformational Analysis Of Antimicrobial Peptides
PROCEEDINGS OF THE 11TH INTERNATIONAL STUDENTS CONFERENCE "MODERN ANALYTICAL CHEMISTRY"(2015)
摘要
We tested the utilization of electronic and vibrational circular dichroism for the conformational study of antimicrobial peptides on two examples: melectin and antapin in different solutions of liposomes and micelles mimicking bacterial or eukaryotic membranes. The results show significant content of the alpha-helical conformation in an environment mimicking the bacterial membrane, while it was considerably low in the eukaryotic membrane-mimicking environment.
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关键词
antimicrobial peptides, circular dichroism, conformation, liposomes, model membranes
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