Development And Performance Test Of Biodegradable Polymer Porous Composite Membrane Micro-Coil Skeleton System

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE(2018)

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摘要
Objective: To make biodegradable porous composite membrane micro-coil (MC) skeleton system with phosphorylchline-grafted chitosan (PC-Chi) and to analyze its mechanical properties. Methods: Based on the restriction of the thickness and pore size of porous membrane, the interfacial bonding tightness of biodegradable polymer materials (chitosan, poly-e-caprolactone and its phosphorylchline grafted polymer) and tungsten, platinum, stainless steel materials was studied by using scratch tester and X-ray diffraction technique. Step-by-step casting, dipping and phase separation were adopted to combine the biodegradable polymer material on MC so as to prepare porous composite membrane MC skeleton system. Scanning electron microscopy was used to observe the adhesion morphology of porous composite membrane on MC. The biosensor was used to measure the tensile strength and elastic modulus of porous composite membrane MC skeleton system. Results: In comparison, the compressive stress of PC-Chi film was the largest; the minimum tensile stress was -243.1 MPa; the peel adhesion-critical load Lc was 5.9N. In this experiment, the binding ability of tungsten was the best. PC-Chi could well cover the surface of tungsten MC, but its elastic stress-strain had no significant difference comparing with common MC. Conclusion: PC-Chi can adhere well to metal surfaces. Within the elastic range, the porous composite membrane MC skeleton system with PC-Chi as coating material has favorable elastic stress and is suitable for practical application.
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关键词
Phosphorylchline-grafted chitosan, X-ray diffraction, thin film, bond stress, scratch method, elastic stress-strain, micro-coil
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