Correlation Analysis Of Integrin Alpha V Beta 3, T-Cadherin, And Vegf Expression In Gastric Cancer Tissue With Microangiogenesis

This study was designed to analyzethe relationship between integrin alpha v beta 3, T-cadherin, and VEGF expression with microvessel density (MVD) and clinicopathological characteristics of gastric cancer. A total of 68 gastric cancer patients and 30 healthy volunteers were enrolled. Serum T-cadherin and VEGF levels were tested by ELISA. Integrin alpha v beta 3, T-cadherin, VEGF, and CD34 expression in gastric cancer tissues and adjacent normal tissues was detected by immunohistochemistry. The relationship between integrin alpha v beta 3, T-cadherin, VEGF, and CD34 expression with MVD and clinicopathological characteristics was analyzed. Serum VEGF level was significantly higher, while T-cadherin was lower in gastric cancer patients compared to those in the normal control group (P < 0.05). Positive rates of integrin alpha v beta 3 and VEGF were higher, MVD counting was larger, and T-cadherin positive rate was lower in gastric cancer tissues than those in the adjacent normal controls (P < 0.05). alpha v beta 3 positive expression was correlated with differentiation, infiltration depth, lymph node metastasis, and TNM staging. VEGF positive expression was related to lymph node metastasis and TNM staging. T-cadherin and CD34 positive expression was associated with differentiation, lymph node metastasis, and TNM staging (P < 0.05). alpha v beta 3 and VEGF expression showed a positive correlation (r = 0.53 and 0.69, respectively; P < 0.05), whereas T-cadherin exhibited a negative correlation with MVD (r = -0.51, P < 0.05). VEGF was positively correlated with alpha v beta 3 (r = 0.58, P < 0.05), while it was negatively correlated with T-cadherin (r = -0.49, P < 0.05). Abnormal expression of integrin alpha v beta 3, T-cadherin, and VEGF was associated with gastric cancer progression and microangiogenesis.