Primary Extraskeletal Myxoid Chondrosarcoma With Adenofibroma Of The Breast: A Case Report And Literatures Review

Primary extraskeletal myxoid chondrosarcoma (EMC) of the breast has been rarely reported. In the present study, the clinical feature, imaging result, pathology, treatment and prognosis of a patient with primary EMC and adenofibroma of the breast were analyzed. A 50-year-old menopausal woman presented at hospital with complaints of the masses in her breasts. Breast ultrasound revealed several masses were found in bilateral breasts. The largest one located at lower outer quadrant in right breast with a clear boundary, irregular shape, uneven echo and blood flow signals, which was 3.3 cm in diameter. Mammography showed multiple nodules were found in bilateral breasts, and most of the boundaries were clear. The largest mass located in the outer quadrant measured 3.0 cm x 3.1 cm in the right breast. After sufficient preparation, the patient received mastectomy in right breast and sentinel lymph node biopsy. Microscopic examination confirmed the largest tumor located in the lower outer quadrant of the right breast was EMC and the tumors in the right outer and upper quadrant were adenofibroma with calcification. The nipple and lymph nodes were not involved. Immunohistochemical staining indicated the EMC were positive for vimentin, S-100 protein, P53 (+ 80%), Ki67 (+ 40%), and focal positive for epithelial membrane antigen, cytokeratin, but negative for cytokeratin 5/6, cytokeratin-H, cytokeratin-L, P63, calponin, smooth muscle actin, estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2. Post operation, the patient did not receive any other treatment and followed up for 18 months, no tumor recurrence and distant metastasis was found.