Protective Effect Of Different Parts Of Terminalia Catappa L. In The Hematological And Biochemical Profiles Of Immunosuppressed Mice

Desi badam botanically equated as Terminalia catappa L. belongs to the family Combretaceae. This tropical tree has gained significance because of the therapeutic potentials of leaves since time immemorial. Existing evidences to validate the medicinal properties of other parts such as bark, fruits, wood are limited. In our previous studies, we have standardized and validated the aqueous extract of bark, fruits and wood of T. catappa using botanical, chemical and analytical protocols. In vitro experiments were also conducted to evaluate the antioxidant, anti-inflammatory, anticancer and antimicrobial properties. In the present study, animal experiments are carried out to evaluate the protective effect of aqueous extract of different parts of T. catappa on cyclophosphamide induced immune-suppressive mice. Low, medium and high doses (125, 250, 500 mg/kg) of the selected plant parts were administered to Swiss albino mice. The effect of test extracts on hematological profile, biochemical profile and histopathological profile was compared with cyclophosphamide (immunosuppressant) treated and levamisole (immunostimulant) treated mice. From the results obtained, it could be concluded that bark, fruit and wood of T. catappa ameliorated cyclophosphamide induced cytotoxicity in mice. Among the different doses, medium dose of the test extracts was more efficacious than the low and high doses.