Clinical Applications of the Mineralized Collagen

This chapter describes clinical applications of the mineralized collagen (MC) for bone defect repair in the fields of orthopedics, stomatology, and neurosurgery, with analyses of clinical cases. Bone defect is a common symptom where the integrality of the bone is damaged. The main reasons leading to bone defect include trauma, bone tumor, degenerative disease, infection, osteomyelitis, and some congenital diseases. As a biomimetic artificial bone repair material that is most similar to human natural bone in terms of composition and microstructure, MC has demonstrated good bone regeneration effects in repairing bone defects at different parts of the body. Especially being mixed with autologous bone marrow, clinical outcomes of the MC are close to autologous bone.