Targeting Hsp-90 Related Disease Entities For Therapeutic Development

Heat shock protein 90 (HSP-90) has been identified in many disease processes including cancer, neurodegeneration, autoimmune diseases, and cancers. Great effort has been expended in the development of specific inhibitors of the N-terminal and C-terminal domains. Inhibitors of post-translational modification have also been developed. Herein, we explore the available inhibitors and those in development, discuss the relevant disease processes, and examine the pitfalls and promises of targeting HSP-90 for therapeutic intervention.