Space Radiation Systems Biology Research In Sj-10 Satellite

Space radiation biology is one of the important parts of space biology, mainly focusing on the mechanisms of biological effects and genetic variations in organisms induced by space radiation. Space radiation biological effects cannot be described by a simple dose-effects relationship due to the complexity of space radiation environment. The diversity of space radiation induced biological mechanisms and the uncertainty of the synergetic interaction between space radiation and microgravity should be considered from the views of multidimensional and systematic ways. The system biology approaches should be used to study the relationships between the space radiation qualities and the space radiation induced biological effects, which are to find the main mechanisms and the key stressors to induce the mutagenic effects. This study investigates the space radiation qualities and the corresponding biological effects with the aid of SJ-10 satellite. The approaches of data mining and system biology are used to analyze these datasets. In the experiment, biological materials (O. sativa seeds, A. thaliana seeds and C. elegans) were located in three different bio-radiation boxes to obtain three distinct radiation environments inside the satellite. The absorbed dose, absorbed dose rate, linear energy transfer, and dose equivalent were measured with the use of active and passive radiation detectors. The biological samples irradiated by the space radiation within the satellite were harvested. After recovery of the satellite, by applying phenotypic and physiological analysis as well as system biology analysis such as genome epigenetic and proteomic scanning to biological samples. The biological changes under different radiation qualities will be analyzed and relevancy between biological effects and radiation parameters will be studied.