The Effect Of Na-22 Uptake Upon Ionic Compartment In Aging Rat Skeletal And Cardiac Muscle

Aim of study is to point out the role of charges distribution at the level of contractile proteins in Contraction and Relaxation state of skeletal and cardiac muscle cells from rats of different ages,by means of Na-22 uptake method in order to bring new arguments in the favor of swelling theory (lateral expansion offilaments network) of muscle contraction in skeletal and cardiac muscle during aging process. Material and method: The study was done on 16 male Wistar rats divided into two groups of 8 rats each: 6 months old and II) 37 months old. The animals were anesthetized and then sacrificed and samples from sartorius skeletal muscle and from papillary muscle from left ventricle were excised and placed in glycerol solution in order to remove cell membranes and to expose the contractile apparatus. Our Na22 uptake studies pointed out another structural aspect offunctional implication of contractile proteins with modified features from 37 months old skeletal and cardiac muscle and the data concerning the charges distribution at the level ofcontractile proteins in Contraction and Relaxation which bring new arguments in the favor of swelling theory( lateral expansion offilaments network) of muscle contraction in skeletal and cardiac muscle during aging process.