Potency Of Air Pollutants At Dna Adduct Formation And Assessment By In Vivo Mutagenesis

Various mutagenic polycyclic aromatic hydrocarbons (PAHs) including nitro-PAHs, associated with suspended particulate matter (SPM), are possibly deposited in the lungs and other organs of residents in urban areas. To assess the mutagenicity of air pollution and its carcinogenic risk in the lung and other organs, it is necessary to assess the genotoxicity in vivo of the various PAHs and nitro-PAHs in urban air. In this chapter, we review the genotoxicity, such as DNA adduct formation, of air pollutants and its assessment by in vivo mutagenesis.