The Change Of Sicam-1 And Pivka-Ii After Treatment Of Hepatocellular Carcinoma As A Predictor Of Patient Survival

Objective: This study aimed to investigate the relationship between the change of sICAM-1 and PIVKA-II after radical resection of hepatocellular carcinoma (HCC) and the prognosis of HCC. Method: Clinical data and prognosis of 137 patients who accepted radical resection of hepatocellular carcinoma were analyzed. Levels of sICAM-1 and PIVKA-II before and 1 month after surgery were examined. All the patients were divided into different groups according to the change of tumor makers after surgery. Survival rates were analyzed statistically between different groups. Result: Patients with sICAM-1 or PIVKA-II over the cutoff level had higher stage of TNM classification and Child-Pugh, higher rates of recurrence and worse survival. Patients with both sICAM-1 and PIVKA-II below the cut off level had the best survival. Conclusion: For the patients who accepted radical resection of HCC, combined analysis on the change of sICAM-1 and PIVKA-II may help to predict the prognosis of HCC.