Tolvaptan Reduces The Risk Of Worsening Renal Function In Patients With Acute Decornpensated Heart Failure And Preserved Left Ventricular Ejection Fraction - Prospective Randomized Controlled Study -

Background: Although the mainstay of treatment for acute decompensated heart failure (ADHF) is decongestion by diuretic therapy, it is often associated with worsening renal function (WRF). The effect of tolvaptan, a selective V2 receptor antagonist, on WRF in ADHF patients with preserved left ventricular ejection fraction (LVEF) is unknown.Methods and Results: We enrolled 50 consecutive ADHF patients whose LVEF on admission was >= 45%. Patients were randomly assigned to either tolvaptan add-on (n=26) or conventional diuretic therapy (n=24). The primary endpoint was the incidence of WRF, defined as an increase in serum creatinine (Cr) >= 0.3mg/dL or 50% above baseline within 48h of randomization. There was no significant difference between the 2 groups in the change in body weight or the total urine volume during 48 h. However, the change in Cr (Delta Cr) at 24 and 48 h after randomization and the incidence of WRF (12% vs. 42%, P=0.0236) were significantly lower, and the fractional excretion of urea (FEUN) at 24 and 48h after randomization was significantly higher in the tolvaptan group. There was an inverse correlation between Delta Cr and FEUN at 48 h after randomization.Conclusions: Tolvaptan can alleviate congestion with a significantly lower risk of WRF in ADHF patients with preserved LVEF, presumably through maintenance of renal perfusion.