Genomics Of Borderline Personality Disorder

Borderline personality disorder (BPD) is comprised of a heterogeneous range of symptoms, including impairment in affect regulation and interpersonal relationships. Dimensional, as well as categorical, diagnostic approaches have been suggested to assess BPD. Twin and family studies indicate that genetic factors contribute to BPD and borderline personality features, and that these are partially shared with the factors influencing personality traits and other psychiatric disorders. The genome-wide association studies that have investigated borderline personality are in line with these observations. However, substantially larger studies are needed to identify the underlying molecular genetic mechanisms of borderline personality. Future genetic research integrating different levels of biological and clinical data has the potential to help guide and monitor personalized diagnosis and treatment. This chapter presents the current state of genetic research into BPD and explores the future contribution of genetic research to a personalized diagnosis and treatment process.