PM455. Genetic Variants in Chromogranin B is Associated with the Risk of Schizophrenia in Korean Male Population

s | 65 receptor abnormalities in schizophrenia may help explain prior epidemiologic data relating the risk for this illness to altered rates of autoimmune disorders, prenatal infection and familial leukemia. Colony stimulating factor 1 receptor (CSF1R) gene encodes a tyrosine kinase growth factor receptor for CSF1, the macrophage and monocyte specific growth factor. CSF1R gene is located at chromosome 5q32, a region that was suggested to be linked to childhood onset schizophrenia. CSF1R gene mutation has been associated with microglial development. In this study, we investigated the genetic association between schizophrenia and single nucleotide polymorphisms (SNPs) of the CSF1R gene. Methods: 219 Korean schizophrenia patients and 379 control subjects were enrolled for this study. We genotyped four SNPs (rs216138, rs10079250, rs2228422 and rs1986027) of the CSF1R gene by direct sequencing. All patients were evaluated by the Operational Criteria Checklist for Psychotic Illness. Multiple logistic regression models (that is, co-dominant, dominant, and recessive) were performed to generate odds ratios, 95% confidence intervals, and p values Results: The genotype frequencies of rs1986027 showed significant association between schizophrenia and control groups [p=0.011 in the co-dominant model (T/T vs. C/C); p=0.003 in the recessive model (T/T vs. C/C + C/T)]. For the SNP rs10079250, significant association was found in the recessive model [(C/C vs. T/T + C/T); p=0.035]. There was no significant association between other two SNP polymorphisms and schizophrenia. Conclusions: Our study is the first to report an association of the CSF1R gene polymorphisms with schizophrenia. We found significant association between CSF1R polymorphism and schizophrenia in Korean population.