In Vitro Magnetic Targeted Delivery Of Doxorubicin Using Iron Oxide Nanoparticles Leads To Enhanced Cell Death In Glioblastoma

Roxana Cristina Popescu,Diana Iulia Savu, Alexandru Daniel Olarescu,Oana Gherasim,Stefan Banita,Mihai Straticiuc,Dragos Mirea,Radu Florin Andrei,Roxana Trusca,Bogdan Stefan Vasile,Gabriel Socol,Ecaterina Andronescu

UNIVERSITY POLITEHNICA OF BUCHAREST SCIENTIFIC BULLETIN SERIES B-CHEMISTRY AND MATERIALS SCIENCE（2020）

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摘要

Iron oxide nanoparticles have been synthesized using a modified Massart method and in situ functionalized with polyethylene glycol, resulting in 8.81 +/- 1.96 nm highly crystalline nanoparticles with spinel structure. Doxorubicin was loaded for magnetic targeted delivery to the peri-nuclear areas of the U-87 MG human glioblastoma cells. Cytotoxicity was dependent on the internalized quantity of the nanoparticles, which varied for each sample.

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关键词

iron oxide nanoparticles, magnetic targeting, drug delivery, Doxorubicin, glioblastoma

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