Exploratory Study Of Changes In Cerebral Cortical Amyloid Betadeposition In Mci Patients With The Supplement Containing Ferulic Acid And Garden Angelica

1547 Purpose: Ferulic acid is a type of polyphenol contained in rice and wheat seeds and is said to have an antioxidant effect and a neuroprotective effect. Study using genetically modified mice showed amyloid beta (Aβ) deposition reduced in the brain of mice given ferulic acid for 6 months. On the other hand, garden angelica is expected to have effects such as acetylcholinesterase inhibition, neurite outgrowth action, and neural network remodeling although the evidence has not been established yet. In Japan, the combination product of ferulic acid and garden angelica is sold as a health supplement. This combination product might reduce Aβ deposition in the human brain and improve cognitive function. In this study, the effect of the supplement containing ferulic acid and garden angelica on Aβ deposition in the brain of mild cognitive impairment (MCI) patients was evaluated exploratorily. Methods: 33 Patients diagnosed with MCI clinically are participated and 23 patients passed MCI diagnosis criteria of J-ADNI and organic disorders that could cause dementia such as cerebrovascular disorders and hydrocephalus were excluded on MRI. They underwent [11C]PiB(Pittsburgh compound B) PET scan. [11C]PiB PET data were acquired by a static brain PET scan 50-70 minutes post injection intravenously. 18 patients of PiB-positive were enrolled in this study. 10 patients took the supplement (1.5g/packet) containing ferulic acid 100mg and garden angelica 20mg twice per day for 24 months. 8 patients did not take the supplement for 24 months. All patients underwent [11C]PiB PET scan 12 months and 24 months after enrolling this study. In [11C]PiB PET data, standard uptake value ratio (SUVR) of Cerebrum cortex and cerebellar cortex ratio was calculated using averaged cerebellar cortical activity as reference. SUVR was also calculated in each region of posterior cingulate gyrus and precuneus, frontal lobe, parietal lobe and temporal lobe and striatal. We evaluated differences of the time course of SUVR between patients with the supplement and without the supplement. Results: The [11C]PiB PET images showed posterior cingulate gyrus and precuneus, frontal lobe, parietal lobe and temporal lobe accumulation in 17 patients and only frontal lobe accumulation in 1 patient without the supplement both 12 months and 24 months after enrolling this study in addition to baseline. Cerebrum cortex average SUVR was 2.19±0.31, 2.31±0.34 and 2.34±0.21 in patients with the supplement and was 2.23±0.48, 2.30±0.50 and 2.31±0.55 in patients without the supplement. SUVR of posterior cingulate gyrus and precuneus, frontal lobe, parietal lobe and temporal lobe and striatal were about 1.8-2.5 in both patients with the supplement and without the supplement. There is not almost change of SUVR from baseline to 24 months after enrolling this study in patients with the supplement and without the supplement. There is not obvious difference of the time course of SUVR between both patients with the supplement and without the supplement. Conclusions: Decrease of Aβ deposition in the brain was not observed by the supplement containing ferulic acid and garden angelica. No significant difference was in the change of the time course of Aβ deposition between patients with the supplement and without the supplement. It is considered that the effect of the supplement is limited usefulness for MCI patients who have Aβ deposition in general clinical situations although there is a possibility of the suppression effect of increasing Aβ deposition in the long term.