Cascade Genetic Testing for Hereditary Cancer Syndromes: A Systematic Review and Meta-Analysis

Objective: In order to fully realize the benefits of cancer genetic testing and disease prevention, genetic testing must be extended to disease-free at-risk relatives with cascade testing. Standard methods for applying cascade testing are lacking, and there is a paucity of literature on rates of testing uptake among disease-free at-risk relatives. The aim of this review was to assess methods and uptake for disease-free at-risk relatives for published strategies of oncologic cascade testing.