Mir-34a As Part of the Chemotherapy Resistance Network in Chronic Lymphocytic Leukemia.

Thorsten Zenz,Julia Mohr,Eric Eldering,Arnon P. Kater,Andreas Buehler,Dirk Winkler,Dirk Kienle,Jan Duerig,Daniel Mertens,Hartmut Doehner,Stephan Stilgenbauer

Blood（2008）

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摘要

The central role of 17p (TP53) deletion and 11q (ATM) deletion in identifying patients with CLL who respond sub-optimally to chemotherapy suggests a prominent role of the DNA damage pathway in CLL. MiR34s have been shown to be direct p53 targets and mediate some of the p53 dependent effects.

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