Mutualism in ecosystems of innovation and entrepreneurship: A bidirectional perspective on universities’ linkages

•University-industry mutualism re-configures the eco-systems actors and impacts.•University-industry mutualism enhances the eco-systems innovative/entrepreneurial culture.•Eco-systems mutualism reinforces university-industry collaborations and impacts.•Mutualism needs well-organized managerial university structures.•Mutualism requires coordination of regulations at different geographical scales.