Does lineage plasticity enable escape from CAR-T cell therapy? Lessons from MLL-r leukemia

Wenjuan Liao,M. Eric Kohler,Terry Fry,Patricia Ernst

Experimental Hematology（2021）

引用 18|浏览9

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摘要

•Increased use of immunotherapy results in unanticipated mechanisms of resistance.•Lineage switching is a mechanism of evasion to CD19-directed immunotherapy.•Multiple cases of lineage switching in MLL-rearranged B-ALL have now been reported.

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关键词

CD19 immunotherapy,KMT2A,MLL1,lineage plasticity,relapse

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