Natural Deep Eutectic Solvents As Sustainable Solvents For Suzuki-Miyaura Cross-Coupling Reactions Applied To Imidazo-Fused Heterocycles

Herein, we present the first Suzuki-Miyaura cross-coupling in a sustainable natural deep eutectic solvent (NaDES) applied to biologically relevant imidazo-fused scaffolds imidazo[1,2-a]pyridine and imidazo[1,2-b]pyridazine. The choline chloride/glycerol (1:2, mol/mol) NaDES allowed the functionalisation of diverse positions on the heterocycles with various boronic acids, by using 2.5 mol% of readily available Pd(OAc)(2). Notably, the catalytic system proceeds without any ligands or additives, without protection from the atmosphere.