Guajamers A-I, Rearranged Polycyclic Phloroglucinol Meroterpenoids from Psidium Guajava Leaves and Their Antibacterial Activity
Chinese journal of chemistry(2021)
摘要
Main observation and conclusion Eight new polycyclic phloroglucinol meroterpenoids guajamers A-H (1-8), a methylated benzoylphloroglucinol meroterpenoid guajamer I (9) representing a new skeleton, and two known analogues (10 and 11) were isolated from the leaves of Psidium guajava. The structures of new molecules were elucidated by detailed analysis of spectroscopic data, and those of 1, 2, 8, and 9 were unambiguously confirmed by single-crystal X-ray diffraction study. Structurally, compounds 1-8 were sesquiterpene and monoterpene- based meroterpenoids with rearranged skeletons, while compound 9 was the first case of 3-alkyl-5-formyl-benzoylphloroglucinol- coupled sesquiterpene containing an unusual C-1-spiro-fused 6/6/9/4 polycyclic skeleton. In addition, all the isolated compounds were evaluated for their antibacterial activity against three bacterial strains, and most of them (compounds 2-7, 10, and 11) showed antibacterial activity against Staphylococcus aureus and Staphylococcus epidermidis with MIC values of 8-32 mu mol/L. These findings suggested that meroterpenoids isolated from Psidium guajava can be considered as potential antibacterial leading compounds for pharmaceutical industry. [GRAPHICS] .
更多查看译文
关键词
Psidium guajava,Meroterpenoids,X-ray crystal structure,Structural elucidation,Antibacterial activity
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要