Line-1 Methylation in Different Vessels, Vascular and Blood Cells in Human Atherosclerosis.

D. V. Sharysh,A. V. Markov,A. A. Sleptcov,N. R. Valiakhmetov,S. A. Vasilyev, O. Y. Vasilyeva,M. S. Nazarenko

Atherosclerosis（2021）

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摘要

Background and Aims: Decreased LINE-1 methylation was associated with cardiovascular diseases. However, LINE-1 methylation in vascular cells is poorly investigated in atherosclerosis. Here we studied DNA methylation of LINE-1 promoter in human carotid atherosclerotic plaque, intact artery, and vein, as well as in vascular smooth muscle cells (VSMC) and macrophages (MPH) isolated from plaques, and in blood cells.

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RNA methylation

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