Fabrication of Antifouling-antibacterial Dual Functional Polymer Coating via Dopamine-based Multiple Interactions

Biomedical device relating bacterial colonization has become a severe issue in clinical practice. To prevent the formation of bacterial biofilm, we develop a facile and versatile one-step codeposition method to readily fabricate an antifouling-antibacterial dual functional polymer coating by virtue of multiple interactions between dopamine derivatives and primary amines in zwitterionic polymer (PMA) and carboxymethyl chitosan (CMC). The presence of DA drives the codeposition of polydopamine (PDA), CMC and PMA, endowing the coating with good durability. While the multiple interactions among CMA, PMA and DA, i.e. hydrogen bonding, Michael addition and/or Schiff base reacions, are beneficial to regulate the oxidation and self-aggregation of DA, eventually achieving a uniformly codeposited polymer coating. Due to the coexistance of zwitterionic antifouling moieties and bactericidal CMC, the resultant CMC-PMA-PDA coating both has the capacity of resisting bacterial adhesion and killing the bacteria adhered on its surface, effectively inhibiting the bacteria biofilm formation.