Characteristics, Treatment Patterns And Outcomes Among Newly Diagnosed Patients (Pts) With Acute Myeloid Leukemia (Aml) Who Present With Hyperleukocytosis: Findings From A Large International Patient Cohort

Introduction: Pts with AML often present with hyperleukocytosis, defined with a white blood cell count (WBC) of >50 or >100 × 109/L. Hyperleukocytosis is associated with higher rates of complications and death especially when associated with clinical leukostasis. There are no clear guidelines outlining the best cytoreductive strategy and the use of leukapheresis is based on institutional practice. Limited data is available regarding characteristics of AML pts with hyperleukocytosis, treatment patterns, short and long-term clinical outcomes.