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Control of S Phase Duration: a Replication Capacity Model with E2F Transcription at Its Heart

Cosetta Bertoli, Robertus A. M. de Bruin

MOLECULAR & CELLULAR ONCOLOGY(2021)

Cited 125|Views2
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Abstract
DNA replication capacity, the maximal amount of DNA a cell can synthesize at any given time during S phase, is controlled by E2F-dependent transcription. Controlling replication capacity limits the replication rate and provides a robust mechanism to keep replication fork speed within an optimal range whilst ensuring timely completion of genome duplication.
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Key words
DNA replication,S phase,DNA replication capacity,E2F-dependent transcription,genome stability
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