The Role Of Egln2/Proline Hydroxylase 1 In Regulation Of Cyclin D1 In Mantle Cell Lymphoma

Mantle cell lymphoma (MCL) is an incurable B-cell non-Hodgkin lymphoma characterized by a translocation that juxtaposes the CCND1 gene (which encodes for cyclin D1) on chromosome 11q13 and an immunoglobulin heavy chain gene promoter on chromosome 14q32. Despite a high rate of complete remission (response 20-80%) by many chemotherapy regimens, MCL typically relapses after treatment, with a median survival time of approximately 3-4 years. Novel therapeutic approaches target several cellular pathways of MCL (CDK, proteasome, mTOR, or NFκB inhibitors and others) but so far have shown only modest effects on overall survival.